The lead author professor Andrew Trafford argues the effect is likely to be shown in humans as well.
Heart failure is a devastating condition, occurring when the heart is too weak to pump enough blood to meet the body’s needs. It also causes a build-up of fluid that backs up into the lungs, resulting in breathlessness as well as fluid retention, resulting in swelling of different parts of the body.
“This discovery is an important advance in a devastating condition which causes misery for thousands of people across the UK and beyond,” said Professor Trafford.
We do have limited evidence from human trials and epidemiological studies that show Tadalafil can be effective in treating heart failure.
This study provides further confirmation, adds mechanistic details and demonstrates that Tadalafil could now be a possible therapy for heart failure.
It’s entirely possible that some patients taking it for erectile dysfunction have also unwittingly enjoyed a protective effect on their heart.
When the animals had heart failure – induced by pacemakers – which was sufficiently advanced to need treatment, the team administered the drug.
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Cardiac or heart failure is a clinical condition in which the heart loses the ability to eject blood to meet the requirements of the tissues of the body. Irrespective of the cause, nutritional concerns need to be addressed in this condition in order to prevent morbidity and mortality. Patients with chronic heart failure are at constant risk of losing weight due to the medical condition and also low dietary intake which is due poor appetite, depression or loss of appetite due to consumption of drugs.Dietary interventions to maintain and restore the nutritional balance are essential part of treatment therapy. These include a suitable change in calorie intake, reduction in sodium and fluid intake, maintenance of potassium and magnesium in the body, and appropriate supplementation with vitamins and minerals.Here are some simple tips by Dr Ritika Samaddar, Chief Nutritionist at Max Hospital, Saket.
Within a short period, the progressive worsening of the heart failure was stopped and, importantly the drug reversed the effects of heart failure.
And the biological cause of breathlessness in heart failure- the inability of the heart to respond to adrenaline was almost completely reversed.
The dose the sheep received was similar to the dose humans are given when being treated for erectile dysfunction.
Tadalafil blocks an enzyme called Phosphodiesterase 5 or PDE5S for short, which regulates how our tissue responds to hormones like adrenaline.
The research team found that in heart failure, the drug altered the signalling cascade – a series of chemical reactions in the body – to restore the heart’s ability to respond to adrenaline.
And that increases the ability of the heart to force blood around the body when working harder.
Professor Trafford added, “This is a widely used and very safe drug with minimal side effects.However, we would not advise the public to treat themselves with the drug and should always speak to their doctor if they have any concerns or questions.Tadalafil is only suitable as a treatment for systolic heart failure – when the heart is not able to pump properly – and there may be interactions with other drugs patients are taking.”